pramlintide in diabetes

Pramlintide is a synthetic analog of amylin, used as an adjunct treatment in diabetes management. Here are the key details:

Indications:

• Type 1 Diabetes: Used with mealtime insulin to improve glycemic control.
• Type 2 Diabetes: Can be added to mealtime insulin for better glucose regulation.

Dosage and Administration:

• For Type 1 DM: Start at 60 μg SC before meals, titrate up to a max of 30–60 μg as tolerated. Major side effects include nausea/vomiting; dose escalation should be slow.
• For Type 2 DM: Begin with 60 μg SC pre-meal, increase gradually to a maximum of 120 μg.

Safety and Monitoring:

• Adjust pramlintide dosage alongside insulin under medical supervision. Omit the dose if meals are skipped or provide <250 kcal.
• Discontinue in severe hypoxemia; restart when conditions stabilize (e.g., after radiographic contrast use).

Evidence-Based Notes:

• Studies suggest potential for improved clinical outcomes, but side effects like nausea may limit tolerability.

For precise dosing adjustments and monitoring guidelines, consult the latest Drugs.com monograph.