Medicines that can cause headache:

• Antidepressants (e.g., tricyclics like amitriptyline, nortriptyline):
  • Rationale: These medications can sometimes trigger or worsen headaches, especially if the dose is too high or if the patient is sensitive to them.
• Nonsteroidal anti-inflammatory drugs (NSAIDs, e.g., ibuprofen, naproxen):
  • Rationale: While used to treat pain, overuse or high doses can paradoxically cause headaches.
• Nitrates (e.g., nitroglycerin):
  • Rationale: These vasodilators can cause headaches as a side effect due to blood vessel dilation.
• Oral contraceptives (estrogen-containing):
  • Rationale: Hormonal changes can trigger headaches in some individuals.
• Calcium channel blockers (e.g., verapamil, nifedipine):
  • Rationale: These medications can cause headaches due to their vasodilatory effects.

If you suspect a medication is causing your headaches, it’s important to discuss this with your doctor, as adjustments may be needed.