Medicines to reduce shaking and rigidity in parkinsons

Based on the information provided, here are some medications commonly used to reduce shaking (tremor) and rigidity in Parkinson's disease. Remember, it's crucial to consult with a healthcare provider to determine the best treatment plan for your specific situation.

1. Levodopa (L-DOPA) + Carbidopa: This is the gold standard treatment for Parkinson's disease. It helps to replace the dopamine that is lost in the brain, which reduces symptoms like tremor and rigidity.
2. Source: RAG Results (Local)

1. Dopamine Agonists: These medications mimic the effects of dopamine in the brain. Examples include pramipexole, ropinirole, and rotigotine (patch). They can be used as an alternative to levodopa or as an adjunct.
2. Source: RAG Results (Local)

1. MAO-B Inhibitors: These help prevent the breakdown of dopamine in the brain. Examples include selegiline, rasagiline, and safinamide.
2. Source: RAG Results (Local)

1. COMT Inhibitors: These help to extend the effects of levodopa. Examples include entacapone, tolcapone, and opicapone. They are usually taken in combination with levodopa.
2. Source: RAG Results (Local)

1. Anticholinergics: These can be useful for tremor, but they are less commonly used due to side effects. Examples include trihexyphenidyl and benztropine.
2. Source: RAG Results (Local)

1. Amantadine: This can be used to treat mild symptoms and is sometimes used to reduce dyskinesias (involuntary movements) caused by levodopa.
2. Source: RAG Results (Local)

Important Notes:

• Motor complications, such as fluctuations in motor response ("on" and "off" episodes) and dyskinesias, often develop after 6 years of levodopa therapy in about 50% of patients.
• Source: RAG Results (Local)

• A controlled-release (CR) preparation of levodopa is available, with 70% bioavailability compared to immediate-release preparations. A dispersible levodopa preparation can be useful for nocturnal hypokinesia and rigidity or for sudden "offs."
• Source: RAG Results (Local)

• Newer medications and treatment strategies may become available, so it's essential to stay up-to-date with your healthcare provider. The recent Australian Government budget has announced cheaper medicines for various conditions, which may include Parkinson's disease medications in the future.
• Source: Web Search Results (Fresh)

Always discuss the potential benefits and side effects of these medications with your doctor. Make sure to inform them about any allergies or other medical conditions you may have to ensure the safest and most effective treatment.